Sequences for targeting metastatic cells
AssigneeBaylor College of Medicine
InventorTimothy C. Thompson
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Abstract
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
Claims3
A method for detecting the presence of metastatic cells in a primary prostate tumor comprising:
- contacting a sample of the tumor with an anti-caveolin antibody that binds to caveolin-1 protein;
- and
- determining the amount of antibody bound to the sample wherein an increase in said amount of bound antibody relative to the amount of antibody bound to a control primary prostate tumor is indicative of the presence of metastatic cells in said primary prostate tumor.
Dependencies are inferred from the claim text.