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US 7,029,849 B2Granted
Method for detecting a risk of hypertension and uses thereof
AssigneeOy Jurilab Ltd
InventorJukka T. Salonen
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Abstract
This invention relates to a method for detecting a risk of hypertension and for targeting antihypertensive treatment in a subject, the method comprising isolating genomic DNA from said subject, determining the DNA sequence comprising a nucleotide sequence encoding a variant α2B-adrenoceptor protein.
Claims21
A method for detecting a risk of hypertension in a subject having a family a history of hypertension by determining the pattern of alleles encoding a variant α2B-adrenoceptor, comprising the steps of:
- a) providing a biological sample of the subject to be tested;
- and
- b) performing an assay on the biological sample for dectecting in the biological sample the presence of
- i) the insertion/insertion (I/I) or deletion/insertion (D/I) genotypes of the human α2B-adrenoceptor, or
- ii) the D/D genotype of the human α2B-adrenoceptor, wherein the presence of the D/D genotype indicates an increased risk of hypertension in said subject.
2 more elements
Dependencies are inferred from the claim text.