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US 7,029,838 B2Granted
Prevascularized contructs for implantation to provide blood perfusion
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsStuart K. Williams, James B. Hoying, Benjamin R. Shepherd
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Abstract
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.
Claims7
A method for vascularizing an engineered tissue in a subject, comprising:
- a. combining at least one prevascularized construct with said engineered tissue, wherein said construct contains freshly isolated autologous microvessel fragments in a biocompatible three-dimensional culture matrix;
- and
- b. implanting said engineered tissue, thereby vascularizing said engineered tissue in vivo.
Dependencies are inferred from the claim text.