Acetaminophen compositions
AssigneeR.P. Scherer Technologies, LLC
InventorsRobert Waranis, Durwin O. Fontenette
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Abstract
The invention herein provides for an oral pharmaceutical composition adapted for use in capsular dosage forms comprising acetaminophen and a lactate salt alone or in combination with an acetate salt. Compositions of the invention exhibit improved solubility characteristics of the active ingredient per given fill volume, thereby permitting the use of smaller capsule sizes to deliver a given effective dose of the active ingredient. Compositions of the invention also exhibit improved clarity per concentration of active ingredient. The invention also provides for a capsular dosage form containing the composition.
Claims15
An oral liquid pharmaceutical composition in a capsule comprising:
- acetaminophen as an active ingredient and a solvent system comprising a l-lactate salt.
An oral liquid pharmaceutical composition comprising:
- acetaminophen in an amount of at least about 40% by weight;
- sodium l-lactate in an amount of at least about 4.0% by weight;
- and potassium acetate in an amount of at least about 4.0% by weight.
A capsule containing an oral liquid pharmaceutical composition comprising:
- acetaminophen as an active ingredient and a solvent system comprising an alkali metal l-lactate salt.
Dependencies are inferred from the claim text.