Variants of Phleum pratense allergenic proteins
AssigneeConsiglio Nazionale Delle Ricerche
InventorsMonica Sturaro, Angelo Viotti, Paolo Falagiani, Giovanni Mistrello, Daniela Roncarolo, Stefania Zanotta
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Abstract
Hypoallergenic variants of the major allergen Ph1 p 1 of Phleum pratense plants and their use in the therapy of the allergic diseases is disclosed.
Claims8
A hypoallergenic protein of the major Ph1 p 1 allergen comprising an amino acid sequence that is homologous by 85% or more to SEQ ID NO. 4, and wherein there are substitutions and/or deletions of at least one of the lysine residues present at positions 28, 35, 44, 48, 179, 183 or 185 of said hypoallergenic protein, and wherein said hypoallergenic protein exhibits reduced IgE reactivity in serum from patients allergic to Phleum pratense pollen as compared to natural Ph1 p 1 allergen.
A protein comprising SEQ ID NO. 2.
Dependencies are inferred from the claim text.