Plasmodium falciparum AMA-1 protein and uses thereof
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsDavid E. Lanar, Sheetij Dutta, Lisa A. Ware, Lalitha P. V. Nair
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Abstract
In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.
Claims20
An isolated polynucleotide encoding the P. falciparum strain 3D7 apical membrane antigen-l (AMA-1) ectodomain protein consisting of amino acids 83–531 of AMA-1.
Dependencies are inferred from the claim text.