US 7,029,671 B1 · Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof

Abstract

The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts thereof [preferred example: (2S,3S,4R)-1-(α-D-galactopyranosyloxy)-2-hexacosanoylamino-3,4-octadecanediol], and to human antigen-presenting cells activated by the method. The invention also relates to a method for treatment of cancer and infectious diseases including AIDS with the activated human antigen-presenting cells, and to a use of the activated human antigen-presenting cells in the preparation of medicines for treating such diseases. The invention can provide a satisfactory therapeutic effect on cancer and infectious diseases including AIDS without the need to pulse the human antigen-presenting cells with tumor antigens.

Claims21

Dependent claims

A method for activating a human antigen-presenting cell, comprising culturing human dendritic cells in vitro with at least one of the glycoside compounds represented by formula (A) or salts thereof and a tumor antigen:

wherein
R1 is H or OH;
X is an integer of from 7 to 25;
R2 is a substituent defined by any one of the following (a) to (e):
(a) —CH2(CH2)YCH3;
(b) —CH(OH)(CH2)YCH3;
(c) —CH(OH)(CH2)YCH(CH3)2;
(d) —CH═CH(CH2)YCH3;
and
(e) —CH(OH)(CH2)YCH(CH3)CH2CH3
wherein Y is an integer of from 5 to 17;
R3 is H;
R4 is OH;
R5 is OH;
R6 is H;
one of R7 and R8 is H and the other is OH;
and
R9 is H, CH3 or CH2OH.

15 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/721,768Filed 27 Nov 2000 · division

Priority

JP 8-35042927 Dec 1996

Granted

18 Apr 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

C07H 15/04
Acyclic radicals, not substituted by cyclic structures: attached to an oxygen atom of the saccharide radical
A61K 40/19
Characterised by the cell type used: dendritic cells
A61K 40/24
Characterised by the effect or the function of the cells: antigen-presenting cells [APC]
A61K 40/42
Vertebrate antigens: cancer antigens

Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof

Life of this patent

Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof

Life of this patent

Abstract

Claims21