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US 7,029,655 B2Granted
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
AssigneeCalifornia Institute of Technology
InventorsMatthew J. Allen, Scott Fraser, Russell E. Jacobs, Thomas J. Meade
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Abstract
The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's disease.
Claims15
An MRI agent comprising:
- a) a chelator;
- b) a lanthanide metal ion;
- and,
- c) an amyloid binding moiety (ABM) comprising (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)-styrylbenzene (BSB) or a derivative thereof.
1 more element
Dependencies are inferred from the claim text.