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US 7,029,631 B2Granted
Apparatus for improved light collection
AssigneeAgilent Technologies, Inc.
InventorsLeslie Leonard, David King
Life of this patent
Estimating the term…
Abstract
An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.
Claims22
An apparatus for enhancing the collection of optical signals that allows for flow of an assay fluid, comprising:
- one or more channel walls defining a channel, said channel adapted for flow of an assay fluid;
- a waveguide, said waveguide comprising a structure, wherein said structure includes at least one portion that protrudes into said channel adapted for assay fluid flow;
- a fluorophore coupled to a surface of said structure, said fluorophore adapted to bind with at least one analyte in said assay fluid, wherein said fluorophore generates one or more new optical signals when said fluorophore binds with said at least one analyte and wherein said structure is adapted to transmit optical signals from said fluorophore through said structure;
- and
- a detector adapted to detect said one or more new optical signals generated from said fluorophore, said detector coupled to said waveguide.
2 more elements
Dependencies are inferred from the claim text.