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US 7,029,630 B2Granted
Ion-sensitive fluorescence optical sensor
AssigneeUniversity of Maryland, Baltimore County
InventorIordan V. Kostov
Life of this patent
Estimating the term…
Abstract
The present invention relates to optical ion sensors, including fluorescence optical ion sensors for use in liquid media in the fields of biology, biotechnology, chemistry, medicine, etc. The present invention provides for optical ion sensors that may be attached to dry hydrophilic or hydrophobic surfaces so as to allow continuous sensing. The optical sensors of the present invention may be sterilized and stored for extended periods of time before use.
Claims17
An optical ion sensor, comprising:
- (a) an adhesive layer;
- (b) a polymeric matrix layer, layered on said adhesive layer, comprising one or more immobilized ion-sensitive indicators;
- and
- (c) an intermediate layer chemically bonding said adhesive layer to said polymeric matrix layer.
1 more element
An optical ion sensor, comprising:
- (a) a silicone rubber layer;
- (b) a polymeric hydrogel layer, layered on said silicone adhesive layer, comprising one or more immobilized ion-sensitive fluorescent dyes;
- (c) an intermediate layer chemically bonding said silicone rubber layer to said polymeric hydrogel layer;
- (d) an optical shield layer layered on said polymeric hydrogel layer;
- (e) a support layer having a first side layered on a side of said silicone rubber layer opposite of said polymeric matrix layer;
- (f) an adhesive layer having a first side layered on a second side of said support layer;
- and
- (g) an adhesive protector layer layered on a second side of said adhesive layer.
5 more elements
A process for producing an optical ion sensor, comprising:
- (a) layering an intermediate layer on a first side of a silicone adhesive layer;
- (b) chemically bonding a polymeric hydrogel layer comprising one or more immobilized ion-sensitive indicators to the intermediate layer;
- (c) layering an optical shield layer on the polymeric hydrogel layer;
- (d) layering a support layer having a first side on a side of the silicone adhesive layer opposite of the polymeric hydrogel layer;
- and
- (e) layering an adhesive layer having a first side on a second side of the support layer.
3 more elements
Dependencies are inferred from the claim text.