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AssigneeInnogenetics N.V.
InventorsGeert Maertens, Fons Bosman, Guy De Martynoff, Marie Ange Buyse
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The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
An isolated E2 specific monoclonal antibody, said antibody specifically binding to at least one region within a domain spanning amino acids 416-650 or 655-809 of the hepatitis C virus polyprotein.
The isolated E2 specific monoclonal antibody secreted by the hybridoma cell line deposited Dec. 3, 1998 with the European Collection or Cell Cultures and assigned the accession number 98031215 or a hybridoma cell line selected from deposit accession numbers DSM ACC 2616 or DSM ACC 2615, each of which were deposited Sep. 10, 2003 with DSMZ.
An isolated E2 specific monoclonal antibody which specifically binds to a region in the E2 domain spanning an amino acid segment selected from the group consisting of 409-428 (SEQ ID NO:73), 427-446 (SEQ ID NO:
Dependencies are inferred from the claim text.