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US 7,026,290 B1Granted
Dispersible concentrate for the delivery of cyclosprin
AssigneeDexcel Ltd.
InventorAbraham J. Domb
Life of this patent
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AssigneeDexcel Ltd.
InventorAbraham J. Domb
Estimating the term…
A formulation for the administration of a cyclosporin. This formulation features a hydrophilic solvent which is characterized by being a lower alkyl ester of hydroxyalkanoic acid; and a surfactant, preferably a combination of a surfactant with a high HLB (hydrophilic/lipophilic balance) of at least about 8 and a surfactant with a low HLB of less than about 5. Other ingredients are optional, such as a fatty acid ester such as tricaprin, a phospholipid, and an ethoxylated fat such as Cremophor or another similar substance. Optionally, the ethoxylated fat is substituted for the surfactant. The preferred particle size of the resultant formulation is less than about 100 nm, more preferably less than about 60 nm, and most preferably from about 5 nm to about 50 nm. The formulation of the present invention is characterized by having high bioavailability.
A composition for administering a cyclosporin compound, the composition comprising:
A composition for administering a cyclosporin compound, the composition comprising:
A method for administering a cyclosporin compound to a subject in need thereof, the method comprising the step of administering a pharmaceutically effective amount of a composition, said composition comprising a dispersible concentrate characterized by being capable of forming, upon contact with an aqueous solution, particles of a size of less than about 100 nm, said dispersible concentrate comprising at least one surfactant and an amphiphilic solvent comprising a lower alkyl hydroxy alkanoic acid ester or a lower alkyl ester of N-alkyl pyrrolidone.
A composition for administering a cyclosporin compound, the composition comprising:
Dependencies are inferred from the claim text.