EIA vaccine and diagnostic
AssigneeAkzo Nobel N.V.
InventorsRonald Montelaro, Bridget Puffer, Feng Li, Charles Issel, Kristina J. Hennessy, Karen K. Brown
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Abstract
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.
Claims7
A method of differentiating a vaccinated mammal from a non-vaccinated mammal, said method comprising:
- a. obtaining a sample from a test mammal;
- and
- b. analyzing said sample for the presence or a gene expression product normally produced by wild-type EIAV but not produced by an EIAV construct used for vaccinating said test mammal.
Dependencies are inferred from the claim text.