Vaccine against Gram-negative bacterial infections
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsApurba Bhattacharjee, Alan Cross, Jerald Sadoff, Wendell Zollinger
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Abstract
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
Claims3
A method of treating Gram negative bacterial sepsis in a subject comprising (a) actively immunizing a first subject with a vaccine comprising a non-covalent complex of a purified, detoxified lipopolysaccharide endotoxin of Escherichia coli strain J5 and a purified outer membrane protein of Neisseria meningitidis;
- (b) collecting from said first subject a post-immune serum or plasma, or IgG isolated therefrom;
- and (c) administering to a second subject an amount of said serum, said plasma, or said IgG that is effective in treating said Gram negative bacterial sepsis.
Dependencies are inferred from the claim text.