Non-human genetically modified mammal lacking the alpha-fetoprotein
AssigneeUniversite Libre de Bruxelles
InventorsPhilippe Gabant, Josiane Roscam-Szpirer
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Abstract
The present invention is related to a non-human genetically modified mammal comprising a mutation, a partial or total deletion of the genetic sequence encoding the wild type mammal alpha-fetoprotein.
Claims3
A sterile female genetically modified mouse which does not undergo menstrual cyclization, wherein the genome of said mouse comprises a mutation, a partial deletion or a total deletion in each allele of endogenous genetic sequence encoding the wild type alpha-fetoprotein (AFP), wherein said mutation, partial deletion or total deletion results in loss of expression of a functional AFP in both alleles.
A method for identifying an agent for use in increasing fertility, comprising:
- obtaining a sterile female genetically modified mouse which does not undergo menstrual cyclization wherein the genome of said mouse comprises a mutation, a partial deletion or a total deletion in each allele of endogenous genetic sequence encoding the wild type alpha-fetoprotein (AFP), wherein said mutation, partial deletion or total deletion results in loss of expression of functional AFP in both alleles;
- contacting said sterile female genetically modified mouse with said agent;
- and
- determining the effects of said agent on fertility in said sterile female genetically modified mouse.
Dependencies are inferred from the claim text.