Preparation of aryl intermediates

A process of making a compound of the formula (A):

• wherein
• P is a nitrogen protecting group chemically suitable for Grignard reagents,
• Y is defined herein below;
• the phenyl ring in (A) is optionally benzo-fused to form naphthyl wherein substituents Y or NH—P can be independently at any position on each of the one or two rings, where the phenyl is not benzo-fused then substitution can be para, meta or ortho;
• said method comprising, in a one pot reaction:
• reacting a compound of the formula (B) with 2 equivalents of R3MgLi, wherein and R3 is C1-5 alkyl, in an aprotic solvent at a temperature between −40° C. to 40° C.:
• wherein X is bromine or iodine,
• subsequently adding an electrophile E as defined herein below,
• to produce a compound of the formula (A)
• wherein E and Y have the following corresponding relationship in the table below:
• E
• Y
• B(O—C1–5alkyl)3
• —B(OH)2
• R′HC═O
• —CHR′—OH
• R′2C(═O)
• —CR′2—OH
• R′X
• —R′
• R′CO2R′
• R′C(═O)—
• R′3SnX
• SnR′3
• R′3SiX
• R′3Si
• R′2(OR′)SiX or
• SiR′2(OR′)
• (R′2SiO)3
• wherein R′ alkyl or aryl, X is halogen.