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US 7,022,882 B2Granted
NMDA receptor channel blocker with neuroprotective activity
AssigneeThe Regents of the University of California
InventorsKwok-Keung Tai, Sylvie E. Blondelle, Richard A. Houghten, Mauricio Montal
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Abstract
Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA receptors, and protect neuronal cells containing such receptors from excitatoxic cell death.
Claims6
A neuroprotectant agent selective for NMDA subtype glutamate receptors in the central nervous system, the agent comprising a compound having the formula:
- wherein R1 is S-4-hydroxylbenzyl or S-2-butyl;
- R2 is benzyl;
- R3 is selected from the group consisting of N-methyl,N-benzylaminobutyl, S-4-hydroxybenzyl (but not when R1 is S-4-hydroxylbenzyl), R-2-naphthylmethyl, S-isopropyl, R-isobutyl and R-2-butyl;
- and R4 is selected from the group consisting of benzyl, methyl, naphthylmethyl and ethyl.
1 more element
Dependencies are inferred from the claim text.