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US 7,022,876 B2Granted
Preparation of mandelic acid derivatives
AssigneeAvecia Limited
InventorsAndrew John Blacker, Ian Nicholas Houson
Life of this patent
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Abstract
A process is provided for the preparation of mandelic acid derivatives. The process comprises the steps of: (a) stereoselectively cyanating a compound of Formula (2) to yield the corresponding cyanohydrin; (b) hydrolyzing the product of step (a) to the corresponding compound of Formula (1). wherein X is a substituent.
Claims9
A process for the catalytic and stereospecific preparation of a compound of Formula (1):
- wherein:
- X is chlorine:
- comprising the steps:
- (a) stereoselectively cyanating a benzaldehyde of Formula (2)
- wherein:
- X is chlorine in the presence of a catalyst of Formula (3), (4), (5) or (5)
- wherein:
- M is V═O
- each M1 is V;
- R1, R2, R3 and R4 are t-butyl;
- and
- Rx and Ry together represent cyclohexyl ring system, to yield the corresponding cyanohydrin, and
- (b) hydrolysing the product of step (a) to the corresponding compound of Formula (1).
10 more elements
A process according to claim 1 or 4 where in step (b) the product of step (a) is hydrolysed by contact with aqueous mineral acid.
Dependencies are inferred from the claim text.