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US 7,022,872 B2Granted
Method for making fluorine labeled L-Dopa
AssigneeMolecular Technologies, Inc.
InventorsJoseph C. Walsh, Henry C. Padgett
Life of this patent
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Abstract
The invention relates to a method for preparing F-Dopa and 18F-Dopa and intermediates that are useful in the method. The invention is a method that synthesizes F-Dopa and 18F-Dopa in good yield with high enantiopurity without the need for further transformations. The method includes the step of reacting a benzaldehyde derivative with a phosphonic acid derivative to produces an olefin intermediate that can be asymmetrically hydrogenated to produce the desired enantiomer.
Claims6
A compound having the following formula:
- wherein R is a methyl group;
- R1 is methoxy;
- R2 is selected from the group consisting of an alkyl having 1 to 4 carbon atoms, and benzyl;
- Y is selected from the group consisting of t-butyloxycarbonyl, formyl, acetyl and benzoyl;
- and X is a halogen.
2 more elements
Dependencies are inferred from the claim text.