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US 7,022,859 B2Granted
Method for the purification of lansoprazole
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsClaude Singer, Anita Liberman, Irena Veinberg, Nina Finkelstein, Tamar Nidam
Life of this patent
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Abstract
The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
Claims15
A method of preparing a lansoprazole containing less than about 0.1% (wt/wt) water, comprising the steps of:
- a) crystallizing a lansoprazole from solution in a solvent that is an organic solvent or a mixture of an organic solvent and water;
- and
- b) isolating the lansoprazole containing less than about 0.1% (wt/wt) water.
Dependencies are inferred from the claim text.