Single pot process for preparing metal nicotinates from beta-picoline
AssigneeJubilant Organosys Limited
InventorsNikhilesh Chandra Bhardwaj, Pradeep Kumar Verma, Agarwal Ashutosh
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Abstract
The present invention relates to a single-pot process for the preparation of metal nicotinates, useful as a dietary supplement, from beta picoline as a source of the starting material, said process comprising the steps hydrosulfonation of beta picoline with sulfuric acid, heating the reaction mixture thus obtained to a temperature of about 150°-210° C. followed by oxidation with a suitable oxidizing agent to obtain nicotinic acid sulfate, reacting the nicotinic acid sulfate with a water soluble zinc and/or chromium salt to produce a solid metal nicotinate and separating it to thereby recover the corresponding metal nicotinates of high purity.
Claims23
A single pot process for the preparation of zinc and/or chromium nicotinates comprising the steps of:
- (a) hydrosulfonating beta picoline, by reaction with sulfuric acid at a temperature of about 35-100° C., to form a reaction mixture;
- (b) further heating the reaction mixture thus obtained to a temperature of about 150°-210° C.;
- (c) oxidizing the reaction mixture of step (b) with an oxidizing agent to form a solution containing nicotinic acid sulfate at a temperature of about 35-90° C.;
- (d) adjusting the pH of the solution of step (c) to a basic solution having a pH of about 7 to 8 and maintaining the pH of said solution;
- (e) treating the basic solution of step (d) with a water soluble zinc and/or chromium salt to produce a solid metal nicotinate in said water, and
- (f) filtering the resulting solid nicotinate to remove such from said water and to thereby obtain the corresponding metal nicotinates of high purity.
A single-pot process for the preparation of metal nicotinates comprising:
- hydrosulfonation of beta picoline with sulfuric acid to produce a reaction mixture;
- heating the reaction mixture thus obtained to an elevated temperature;
- oxidizing the heated reaction mixture under conditions sufficient to obtain nicotinic acid sulfate;
- reacting the nicotinic acid sulfate with a water soluble zinc and/or chromium salt to produce a solid metal nicotinate;
- and
- separating solid metal nicotinate of high purity from the reaction product.
Dependencies are inferred from the claim text.