US 7,022,852 B2 · Process for preparing inhibitors of nucleoside metabolism

Abstract

A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), to form a compound of formula (XX) The compound of formula (LXX) is N- and O-deprotected to obtain the compound of formula (I).

Claims4

Dependent claims

A compound of formula (XX):

wherein R9 is a hydrogen atom, an alkoxycarbonyl or aralkyloxycarbonyl group, Z′ is a hydrogen or halogen atom, a hydroxy group, a group of formula SQ or OQ, or a trialkylsilyloxy, alkyldiarylsilyloxy or optionally substituted triarylmethoxy group and Q is an optionally substituted alkyl, aralkyl or aryl group, and R6 is an N-protecting group, B′ and D′ are independently selected from H, OR7 and N(R8)2, and R7 and R8 are O- and N-protecting groups respectively.

Dependencies are inferred from the claim text.

Facts

Application

10/737,724Filed 16 Dec 2003 · continuation

Priority

NZ 3350908 Apr 1999

Published

US 2004/0181063 A116 Sep 2004

Granted

4 Apr 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 207/416
2,5-Pyrrolidine-diones: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester…
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07D 487/04
In which the condensed system contains two hetero rings: ortho-condensed systems

Family

PCT/NZ00/00048Parent of this continuation · filed 7 Apr 2000

US 6,693,193 B1Parent of this continuation · filed 17 Feb 2004

US 2004/0181063 A1Pre-grant publication · published 16 Sep 2004

Application09/958,219Parent of this continuation

US 7,022,852 B2This patent

From the US filing history. Foreign family members aren’t listed.

Process for preparing inhibitors of nucleoside metabolism

Life of this patent

Process for preparing inhibitors of nucleoside metabolism

Life of this patent

Abstract

Claims4