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US 7,022,847 B2Granted
Method for the production of 2-(2-ethoxyphenyl)-substituted imidazotriazinones
AssigneeBayer HealthCare LLC
InventorsMarc Nowakowski, Alexander Vetter
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Abstract
The invention relates to a method for the production of 2-phenyl-substituted imidazotriazinones of general formula (I), comprising the reaction of compounds of formula (II) with compounds of formula (III) and subsequent reaction with iodine or bromine, then with a metal cyanide and reaction with an acid.
Claims10
Process for preparing a compound of the formula (I)
- in which
- R1 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms,
- R2 represents straight-chain alkyl having up to 4 carbon atoms,
- R3 and R4 are identical or different and represent hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, or represent straight-chain or branched alkoxy having up to 6 carbon atoms,
- comprising reaction of a compound of the formula (II)
- in which R2, R3 and R4 have the meaning indicated above, with a compound of the formula (III)
- in which
- R1 has the meaning indicated above,
- X represents halogen;
- in the presence of a base and, where appropriate, of a metal iodide in an organic solvent to give a compound of the formula (IV)
- in which R1, R2, R3 and R4 have the meaning indicated above, and subsequent reaction
- [A] with iodine in the presence of a base in a solvent, subsequent reaction with a metal cyanide in a solvent and reaction with an acid
- or
- [B] with bromine in acidic medium, subsequent reaction with a metal cyanide in a solvent and reaction with an acid.
11 more elements
Dependencies are inferred from the claim text.