US 7,022,842 B2 · Process for synthesizing beta-lactam

Abstract

It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200° C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

Claims10

Dependent claims

A method for synthesizing a β-lactam comprising reacting a β-amino acid in water in a reaction vessel at high-temperature and under high-pressure conditions for a reaction time of 0.001 seconds to 10 minutes to synthesize the β-lactam;

wherein the temperature range is 200 ° C. or higher;
wherein the pressure range is 10 MPa or higher;
wherein β-lactam is expressed by the formula:
wherein R1, R2, R3, R4 and R5 may be the same or different groups, and respectively indicate hydrogen, halogen, alkyl groups, phenyl groups, phenylalkyl groups, aryl groups, cycloalkyl groups, atkenyl groups, or arylalkyl groups with 1 to 15 carbon atoms, which may be unsubstituted or substituted by substituent groups;
and
wherein the substituent groups are halogen atoms, amido groups, nitro groups, alkoxy groups, acetoxy groups, hydroxyl groups, mercapto groups, phosphoric acid groups, tosyl groups, acyl groups, imido groups, phosphine groups, nitrile groups, or alkylsilyl groups.

3 more elements

Dependencies are inferred from the claim text.

Process for synthesizing beta-lactam

Life of this patent

Process for synthesizing beta-lactam

Life of this patent

Abstract

Claims10