Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against RNA targets and its preparation
AssigneeKorea Institute of Science and Technology
InventorsJaehoon Yu, Jongkook Lee, Miyun Kwon, Kye-Jung Shin
Life of this patent
Estimating the term…
Abstract
The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.
Claims6
A neomycin-chloramphenicol heterodimer represented by formula 1:
- wherein, n is an integer of 2–10.
Dependencies are inferred from the claim text.