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US 7,022,739 B2Granted
Substituted 1-aminobutan-3-ol compounds
AssigneeGruenenthal GmbH
InventorsHelmut Buschmann, Corinna Maul, Bernd Sundermann, Utz-Peter Jagusch, Michael Haurand, Boris Chizh
Life of this patent
Estimating the term…
Abstract
Substituted 1-aminobutane-3-ol compounds, methods for producing them, pharmaceutical compounds containing them, and the use of substituted 1-aminobutane-3-ol compounds for producing pharmaceutical compounds.
Claims34
A substituted 1-aminobutan-3-ol compound corresponding to the formula I
- wherein
- R1 and R2 together form a (CH2)2-9 ring that may optionally be substituted with C1-8-alkyl that is branched or unbranched, saturated or unsaturated, unsubstituted or singly or multiply substituted;
- or aryl that is unsubstituted or singly or multiply substituted,
- R3 and R4 are each independently selected from the group consisting of C1-6-alkyl that is branched or unbranched, saturated or unsaturated, unsubstituted or singly or multiply substituted;
- C3-6-cycloalkyl that is saturated or unsaturated, unsubstituted or singly or multiply substituted;
- phenyl, benzyl or phenethyl that is unsubstituted or singly or multiply substituted, or
- R3 and R4 together form a ring and denote CH2CH2OCH2CH2, CH2CH2NR22CH2CH2 or (CH2)3-6
- where R22 is selected from the group consisting of H;
- C1-10-alkyl or C3-10-cycloalkyl, in each case saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted;
- aryl or heteroaryl, in each case singly or multiply substituted or unsubstituted;
- or aryl, C3-10-cycloalkyl or heteroaryl, in each case singly or multiply substituted or unsubstituted, and that is bound via a saturated or unsaturated C1-3-alkyl group;
- R5 is selected from the group consisting of C1-10-alkyl that is saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted;
- saturated or unsaturated C3-9-cycloalkyl;
- aryl, heteroaryl, aryl bound via saturated or unsaturated C1-3-alkyl, C3-10-cycloalkyl bound via saturated or unsaturated C1-3-alkyl or heteroaryl bound via saturated or unsaturated C1-3-alkyl, wherein the aryl, heteroaryl or cycloalkyl groups may each independently be unsubstituted or singly or multiply substituted with radicals selected independently of one another from the group consisting of
- F, Cl, Br, I, OR18, SR18, SO2R18, SO2OR18, CN, COOR18, NR19R20;
- C1-10-alkyl that is saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted;
- C3-9-cycloalkyl that is saturated or unsaturated, unsubstituted or singly or multiply substituted;
- aryl or heteroaryl, in each case unsubstituted or singly or multiply substituted;
- or aryl bound via saturated or unsaturated C1-3-alkyl, C3-9-cycloalkyl or heteroaryl, in each case unsubstituted or singly or multiply substituted;
- where R18 is selected from the group consisting of H;
- C1-10-alkyl that is saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted;
- C3-9-cycloalkyl that is saturated or unsaturated, unsubstituted or singly or multiply substituted;
- aryl or heteroaryl that is unsubstituted or singly or multiply substituted;
- or aryl bound via saturated or unsaturated C1-3-alkyl, C3-9-cycloalkyl or heteroaryl, in each case unsubstituted or singly or multiply substituted;
- R19 and R20 are independently selected from the group consisting of H;
- C1-10-alkyl that is saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted;
- C3-9-cycloalkyl that is saturated or unsaturated, unsubstituted or singly or multiply substituted;
- aryl or heteroaryl in each case unsubstituted or singly or multiply substituted;
- or aryl bound via saturated or unsaturated C1-3-alkyl, C3-9-cycloalkyl or heteroaryl, in each case unsubstituted or singly or multiply substituted;
- or R19 and R20 together form CH2CH2OCH2CH2, CH2CH2NR21CH2CH2 or (CH2)3-6,
- where R21 is selected from the group consisting of H, C1-10-alkyl that is saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted;
- R6 is selected from the group consisting of H;
- aryl or heteroaryl in each case unsubstituted or singly or multiply substituted;
- and
- R7 is selected from the group consisting of halogen, CF3;
- C1-6-alkyl that is branched or unbranched, saturated or unsaturated, unsubstituted or singly or multiply substituted;
- C3-9-cycloalkyl that is saturated or unsaturated, unsubstituted or singly or multiply substituted;
- aryl, heteroaryl that is in each case unsubstituted or singly or multiply substituted;
- aryl bound via saturated or unsaturated C1-3-alkyl, C3-9-cycloalkyl or heteroaryl, in each case unsubstituted or singly or multiply substituted
- optionally in the form of a racemate, a pure stereoisomer, an enantiomer or diastereomer, or a mixture of stereoisomers, of enantiomers or diastereomers, in an arbitrary mixture ratio;
- or a free acid or a free base or a physiologically acceptable salt, or a solvate or hydrate.
38 more elements
Dependencies are inferred from the claim text.