Treatment of septic shock
AssigneeMolichem Medicines, Inc.
InventorsWieslaw Mieczyslaw Kazmierski, Luis Molina
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Abstract
The use of transition metal complexes in the treatment of septic shock, in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexes in the treatment of other conditions caused by pathological NO production are also disclosed.
Claims6
A method of treating septic shock comprising administering to a mammal in need thereof an effective amount of a transition metal complex, wherein said transition metal complex comprises iron linked to a ligand selected from the group consisting of a compound of Formula IV:
- wherein R16 is a C1-6 alkyl chain optionally substituted by a —COOH group or a group—NR17R18 wherein R17 and R18 are each hydrogen or a C1-4 alkyl optionally substituted with a —COOH group;
- and wherein said administering step is carried out by oral, parenteral or topical administration.
Dependencies are inferred from the claim text.