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AssigneesNisshin Pharma Inc., Kyorin Pharmaceutical Co., Ltd.
InventorsMasahiro Ueno, Koji Kawamura, Makoto Yanai, Toshihiro Takahashi, Nobuhiro Kinoshita, Koichi Katsuyama, Satoko Fuchizawa, Shigeru Hiramoto
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This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.
A 2-(S)-hydroxy-3-substituted propanolamine derivative having a 6-substituted 2,3-dihydro-1,4-benzodioxine ring wherein the 2-position is substituted with a carboxy group or a (C1–C6)alkoxycarbonyl group and is provided with R configuration, represented by formula (II):
A pharmaceutical composition which comprises a compound as claimed in any of claims 1, 2 or 6 or a pharmacologically acceptable salt thereof as an active ingredient and, if necessary, pharmaceutically acceptable auxiliaries.
A therapeutic agent for diabetes, obesity or hyperlipemia in a mammal which comprises a compound as claimed in any of claims 1, 2 or 6 or a pharmacologically acceptable salt thereof as an active ingredient.
A method of treating diabetes, obesity or hyperlipemia in a mammal in need of such treatment or prevention, which comprises administering to the mammal, an effective amount of a compound as claimed in any of claims 1, 2 or 6 or a pharmacologically acceptable salt thereof.
A compound selected from the following compounds:
Dependencies are inferred from the claim text.