Platelet ADP receptor inhibitors

A compound selected from the group consisting of formula (I) and formula (II):

• wherein
• A is thienyl optionally substituted with one, two or three substituents independently selected from the group consisting of lower alkoxy, lower alkyl, loweralkylamino, hydroxy, halogen, cyano, hydroxyl, mercapto, nitro, thioalkoxy, carboxaldehyde, carboxyl, carboalkoxy and carboxamide;
• W is 1,4-phenylene optionally substituted with one, two or three substituents independently selected from the group consisting of lower alkoxy, lower alkyl, lower alkylamino, hydroxy, halogen, cyano, hydroxyl, mercapto, nitro, thioalkoxy, carboxaldehyde, carboxyl, carboalkoxy and carboxamide;
• E is selected from the group consisting of H, —C1–C8 alkyl, polyhaloalkyl, —C3-8-cycloalkyl, aryl optionally substituted with one, two or three substituents independently selected from the group consisting of lower alkoxy, lower alkyl, lower alkylamino, hydroxy, halogen, cyano, hydroxyl, mercapto, nitro, thioalkoxy, carboxaldehyde, carboxyl, carboalkoxy and carboxamide;
• D is
• wherein:
• n is an integer from 0–4,
• X is in each case a member independently selected from the group consisting of:
• halogen, polyhaloalkyl, —OR3, —SR3, —CN, —NO2, —SO2R3—C1-10-alkyl, —C3-8-cycloalkyl, aryl, aryl-substituted by 1–4 R3 groups, amino, amino-C1-8-alkyl, C1-3-acylamino, C1-3-acylamino-C1-8-alkyl, C1-6-alkylamino, C1-6-alkylamino C1-8 alkyl, C1-6 dialkylamino, C1-6 dialkylamino C1-8 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6-alkyl, carboxy-C1-6-alkyl, C1-3-alkoxycarbonyl, C1-3-alkoxycarbonyl-C1-6-alkyl, carboxy C1-6 alkyloxy, hydroxy, hydroxy C1-6alkyl, and a 5 to 10 membered fused or non-fused aromatic or nonaromatic heterocyclic ring system, having 1 to 4 heteroatoms independently selected from N, O, and S, with the proviso that the carbon and nitrogen atoms, when present in the heterocyclic ring system, are unsubstituted, mono- or di-substituted independently with 0–2 R4 groups,
• wherein R3 and R4 are each independently selected from the group consisting of:
• hydrogen, halogen, —CN, —NO2, —C1-10 alkyl, C3-8-cycloalkyl, aryl, amino, amino-C1-8-alkyl, C1-3-acylamino, C1-3-acylamino-C1-8-alkyl, C1-6-alkylamino, C1-6-alkylamino C1-8 alkyl, C1-6 dialkylamino, C1-6 dialkylannino C1-8 alkyl, C1-6 alkoxy, C1-6 alkoxy —C1-6-alkyl, carboxy-C1-6-alkyl, C1-3-alkoxycarbonyl, C1-3-alkoxycarbonyl-C1-6-alkyl, carboxy-C1-6-alkyloxy, hydroxy, hydroxy-C1-6-alkyl, -thio and thio-C1-6-alkyl;
• Y is selected from the group consisting of O, S, N—OR5, and NR5,
• wherein R5 is selected from the group consisting of:
• H, C1-10 alkyl, C3-8-cycloalkyl, and CN;
• or pharmaceutically acceptable salts thereof.