US 7,022,721 B1Granted

Method and composition for rejuvenating cells, tissues, organs, hair and nails

OwnerPeter C Ulrich, Sheng Ding Fang +3inventors

InventorsPeter C Ulrich, Sheng Ding Fang, Michael L Brines, Qiao-Wen Xie, Anthony Cerami

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Abstract

In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

Claims1

Dependent claims

A composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected form the group consisting of compounds of the formula (I):

wherein
R′ is a C1–C18 alkyl group —CH(R5)—OH, or the group —CH(R5)—OC(═O)—R6 wherein R5 is a C1-18 alkyl group and R6 is selected from the group consisting of C1–C18 alkyl, phenyl, halosubstituted phenyl, C1–C18 alkoxysubstituted phenyl and naphthyl;
R2 is selected from the group consisting of hydroxy, phenyl, halosubstituted phenyl, C1–C18 alkoxysubstituted phenyl, a C5-7 aromatic, unsaturated or saturated heterocyclic ring having one to three heteroatoms selected from the group consisting of N, O and S;
R3 and R4 together with their ring atoms may be an aromatic ring system of 6–10 carbons, optionally substituted with one or more halo, lower alkyl, lower alkoxy, or amino groups;
and
X− is halide or other pharmaceutically acceptable anion.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/794,024Filed 8 Mar 2004 · division
Priority: 7 Feb 2001
Granted: 4 Apr 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/428
Thiazoles: condensed with carbocyclic rings
A61K 8/49
Containing organic compounds: containing heterocyclic compounds
A61Q 3/02
Manicure or pedicure preparations: nail coatings
A61Q 5/02
Preparations for care of the hair: preparations for cleaning the hair

Family

Application60/267,226Us provisional application · filed 7 Feb 2001
Application10/072,712Parent of this division · filed 7 Feb 2002
US 6,777,557 B2Parent of this division
US 2002/0188015 A1Published application
US 7,022,721 B1This patent

From the US filing history. Foreign family members aren’t listed.