Aryl substituted benzimidazoles and their use as sodium channel blockers

A compound having the Formula I:

• or a pharmaceutically acceptable salt, or solvate thereof, wherein:
• R1 is selected from the group consisting of:
• where
• Y is an optionally substituted C2-6 alkylene, and
• R3 and R4 together with the nitrogen to which they are attached form a ring having 4 or 5 carbon atoms, which ring optionally contains 1 or 2 additional heteroatoms independently selected from oxygen and NR5, where R5 is hydrogen or alkyl, or said ring is optionally substituted with an alkyl or aryl moiety;
• and
• (ii) piperidin-4-ylalkyl, optionally substituted by alkyl, aryl or aralkyl;
• R2 is selected from the group consisting of:
• (i) optionally substituted phenoxyphenyl;
• (ii) optionally substituted benzyloxyphenyl;
• (iii) optionally substituted phenylthiophenyl;
• (iv) optionally substituted benzylthiophenyl;
• (v) optionally substituted phenylaminophenyl;
• (vi) optionally substituted benzylaminophenyl;
• wherein R6 and R7 are independently halogen, alkyl, alkoxy or haloalkyl;
• and p and q are integers from 0 to 4;
• wherein R8 is hydrogen, halogen, alkyl or alkoxy;
• wherein R9 is hydrogen or alkyl;
• and
• (x) naphthalyl;
• R10 is selected from halogen, hydroxy, alkyl, alkoxy and alkoxyalkyl, wherein any alkyl moiety of R10 can be optionally substituted by one or more of halogen or hydroxy;
• and
• n is an integer from 0 to 4, where when n is 0, R10 is absent and the benzene ring of the benzimidazole compound has four hydrogen atoms attached thereto, and when R10 is present, R10 replaces one or more of the available hydrogen atoms on the benzene ring of the benzimidazole compound.