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US 7,022,711 B2Granted
2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones
AssigneeWarner-Lambert Company
InventorsJames Marino Hamby, Sylvester Klutchko, James Bernard Kramer
Life of this patent
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Abstract
This invention provides antiangiogenic compounds of the Formula (I), which are useful for treating diseases, resulting from uncontrolled cellular proliferation such as cancer, atherosclerosis, rheumatoid arthritis, and psoriasis.
Claims20
A compound of Formula I
- wherein:
- R1, R2, R5, and R6 independently are hydrogen, halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, C1–C6 alkanoyl, —CN, —NO2, C1–C6 alkanoyloxy, COOR8, —CF3, NR8R9, or (X)m-(CH2)n—NR8R9, where R8 and R9 independently are hydrogen, C1–C6 alkyl, C1–C6 alkanoyl, or R8 and R9 taken together with the nitrogen to which they are attached can complete a ring having 3 to 7 carbon atoms and optionally containing 1, 2, or 3 ring heteroatoms selected from the group consisting of nitrogen, substituted nitrogen, oxygen, and sulfur;
- X is NH or O;
- m is 0 or 1;
- n is 0 to 6;
- provided m and n are not both 0;
- R3 and R4 independently are C1–C6 alkyl or halo substituted C1–C6 alkyl;
- R7 is hydrogen, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, or C3–C6 cycloalkyl.
5 more elements
The compound 6-(3,5-dimethyoxy-phenyl)-8-ethyl-2-(pyridine-4-ylamino)-8H-pyrido[2,3-d]pyrimidine-7-one.
The compound which is:
- 6-(3,5-Dimethoxy-phenyl)-2-(2-methyl-pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-(2,6-dimethyl-pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-(2-chloro-pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-(2,6-dimethoxy-pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-(pyridin-4-ylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(2-Chloro-3,5-dimethoxy-phenyl)-2-(pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-2-(pyridin-4-ylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-(pyridin-4-ylamino)-8–-cyclopentyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-[2-(4-methylpiperizinyl)pyridin-4-ylamino]-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- 6-(3,5-Dimethoxy-phenyl)-2-[2-(2-dimethylaminoethoxy)-pyridin-4-ylamino]-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one;
- and
- 6-(3,5-Dimethoxy-phenyl)-2-[2-(2-diethylaminoethylamino)-pyridin-4-ylamino]-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one.
9 more elements
A pharmaceutical composition comprising 6-(3,5-dimethoxy-phenyl)-8-ethyl-2-(pyridine-4-ylamino)-8H-pyrido[2,3-d]pyrimidine-7-one together with an excipient, carrier, or diluent thereof.
Dependencies are inferred from the claim text.