Selective PDE 2 inhibitors as pharmaceuticals for improving perception
OwnerFrank-Gerhard Böss, Martin Hendrix +6inventors
InventorsFrank-Gerhard Böss, Martin Hendrix, Gerhard König, Ulrich Niewöhner, Karl-Heinz Schlemmer, Rudy Schreiber, Franz-Josef Van Der Staay, Dagmar Schauss
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Abstract
The invention relates to the use of selective phosphodiesterase 2 (PDE 2) inhibitors for producing pharmaceuticals for improving perception, concentration, learning and/or memory.
Claims2
A method for treating a disorder of perception, concentration, learning and/or memory, where said disorder of perception, concentration, learning and/or memory is a result of Alzheimer's disease, comprising administering to a mammal in need of such treatment an effective amount of a selective PDE 2 inhibitor which inhibits human PDE 2 more strongly than it inhibits the human cAMP PDEs 3B, 4B and 7B, and which has the general formula (I)
- wherein
- A=D represents N═N, N═CH or CR5═N, in which R5 denotes hydrogen, methyl, ethyl or methoxy,
- R1 and R2 represent, together with the adjacent carbon atom, hydroxymethylene or carbonyl, and
- R3 and R4 represent independently of one another methyl, ethyl, methoxy, ethoxy or a radical of the formula SO2NR6R7,
- in which
- R6 and R7 denote, independently of one another, hydrogen, C1–C6-alkyl, C3–C7-cycloalkyl, or
- R6 and R7 form, together with the adjacent nitrogen atom, an azetidin-1-yl, pyrrol-1-yl, piperid-1-yl, azepin-1-yl, 4-methylpiperazin-1-yl or morpholin-1-yl radical,
- or a pharmaceutically acceptable salt thereof.
A method for treating a disorder of perception, concentration, learning and/or memory, where said disorder of perception, concentration, learning and/or memory is a result of Parkinson's disease, comprising administering to a mammal in need of such treatment an effective amount of a selective PDE 2 inhibitor which inhibits human PDE 2 more strongly than it inhibits the human cAMP PDEs 3B, 4B and 7B, and which has the general formula (I)
- wherein
- A=D represents N═N, N═CH or CR5═N, in which R5 denotes hydrogen, methyl, ethyl or methoxy,
- R1 and R2 represent, together with the adjacent carbon atom, hydroxymethylene or carbonyl, and
- R3 and R4 represent independently of one another methyl, ethyl, methoxy, ethoxy or a radical of the formula SO2NR6R7,
- in which
- R6 and R7 denote, independently of one another, hydrogen, C1–C6-alkyl, C3–C7-cycloalkyl, or
- R6 and R7 form, together with the adjacent nitrogen atom, an azetidin-1-yl, pyrrol-1-yl, piperid-1-yl, azepin-1-yl, 4-methylpiperazin-1-yl or morpholin-1-yl radical,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.