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US 7,022,708 B2Granted
4-piperazinyl benzenesulfonyl indoles and uses thereof
AssigneeRoche Palo Alto LLC
InventorsRobin Douglas Clark, Ralph New Harris, III, David Bruce Repke
Life of this patent
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Abstract
This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
Claims32
A compound of the formula:
- wherein:
- R1 and R2 each independently is hydrogen, alkyl, aryl, halo, nitro, amino, cyano, alkoxy, hydroxy, aryloxy, alkylthio, arylthio, thiol, carbonylamino, aminocarbonyl, or haloalkyl;
- R3 and R4 each independently is hydrogen, halo, alkyl, aryl, or arylalkyl;
- R5 is:
- n is 0 to 4;
- R6 in each independent occurrence is hydrogen, alkyl, alkoxy, or halo;
- R7 and R8 each independently is hydrogen or alkyl;
- and
- R9 is hydrogen, alkyl, or arylalkyl;
- or an individual isomer, a racemic or non racemic mixture of isomers, a prodrug, or a pharmaceutically acceptable salt or solvate thereof.
7 more elements
Dependencies are inferred from the claim text.