Thioether-substituted benzamides as inhibitors of Factor Xa

A compound having the formula:

• or a pharmaceutically acceptable salt thereof,
• wherein
• R1a is a member selected from the group consisting of H, halogen, hydroxy, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, (C1-6 alkyl)0-2amino and C1-6 alkylcarbonyl;
• R1b and R1c are each members independently selected from the group consisting of H and C1-6 alkyl, or optionally, R1b and R1c are combined with the nitrogen atom to which each is attached to form a 5-, 6- or 7-membered monocyclic ring having from 0 to 1 additional heteroatom ring members or an 8-, 9-, 10- or 11-membered bicyclic ring having 0–2 additional heteroatom ring members, said heteroatom ring members selected from O, N, S, S(O) and S(O)2, said ring being further substituted with from zero to two substituents independently selected from the group consisting of C1-6 alkyl, (C1-6 alkyl)0-2amino, oxo and an amine protecting group;
• R1d and R1e are each members independently selected from the group consisting of H, halogen, hydroxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, (C1-6 alkyl)0-2amino and aminoC1-6 alkyl;
• or R1d and R1e are combined to form a fused 5–6 membered ring having 0–2 ring heteroatoms selected from N, O and S;
• X is O, S or together with the carbon atom to which it is attached is CH2;
• Y is CH or N;
• and
• Z is a group having the formula:
• wherein
• R2a, R2b and R2c are each members independently selected from the group consisting of H, hydroxy, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy and (C1-6 alkyl)0-2amino;
• or optionally, any two of R2a, R2b and R2c are taken together with their intervening atom(s) to form a 3-, 4-, 5-, 6- or 7-membered ring having from 0 to 1 additional heteroatom ring members selected from O, N, S, S(O) and S(O)2, said ring being further substituted with from zero to two substituents independently selected from the group consisting of C1-6 alkyl, hydroxy, C1-6 alkoxy, CO2H, oxo and (C1-6 alkyl)0-2amino.