Processes for the preparation of 6-11 bicyclic erythromycin derivatives

A process comprising the step of reacting a compound of formula (I):

• or a pharmaceutically acceptable salt thereof, with a compound of formula II:
• to produce a compound of formula III:
• wherein,
• Each R1 is independently hydrogen, acyl, silane, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, saturated or unsaturated heterocyclic group;
• Each of R3 and R4 is independently hydrogen, acyl, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, saturated or unsaturated heterocyclic group;
• or can be taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted heterocyclic or heteroaromatic ring;
• Q is independently R1, OR1, or OC(O)R1;
• Z is R1, OR1, OC(O)R1, OC(O)NR3R4, OS(O)nR1, or
• one of J or G is hydrogen and the other is R1, OR1, or NR3R4;
• or, J and G, taken together with the carbon atom to which they are attached, are C═O, C═NR1, C═NOR1, C═NO(CH2)mR1, C═NNHR1, C═NNHCOR1, C═NNHCONR3R4, C═NNHS(O)nR1, or C═N—N═CHR1;
• R11 is independently R1;
• Rp is independently R1;
• m is an integer between 1 and about 24;
• and
• n is 0, 1, or 2.