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US 7,022,678 B2Granted
Pregabalin lactose conjugates
AssigneeWarner-Lambert Company
InventorsTimothy Robert Hurley, Michael James Lovdahl, Brian Tobias
Life of this patent
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Abstract
In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.
Claims5
A compound selected from:
- (S)-1-[3,4-Dihydroxy-6-hydroxymethyl-5-(3,4,5-trihydroxymethyl tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl]-4-isobutyl-pyrrolidin 2-one;
- (S)-4-Isobutyl-1-(2,3,4,5-tetrahydroxy-tetrahydro-pyran 2-ylmethyl)-pyrrolidin-2-one;
- (S)-1-[2,3-Dihydroxy-5-hydroxymethyl-4-(3,4,5-trihydroxy-6 hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl]-4-isobutyl-pyrrolidin-2-one;
- (S)-4-Isobutyl-1-[2,3,5-trihydroxy-4-(3,4,5-trihydroxy 6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl]-pyrrolidin-2-one;
- and
- (S)-4-Isobutyl-1-(2,3,4-trihydroxy-5-hydroxymethyl-tetrahydro furan-2-ylmethyl)-pyrrolidin-2-one.
3 more elements
A compound having the formula
Dependencies are inferred from the claim text.