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US 7,022,675 B2Granted
Wound healing compositions
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere S. DiZerega
Life of this patent
Estimating the term…
Abstract
Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.
Claims26
A polypeptide comprising at least five contiguous amino acids of a general formula selected from the group consisting of
- R1-Arg-norLeu-R3-R4-His-Pro-R5,
- R1-Arg-R2-homoSer-R4-His-Pro-R5, and
- R1-Arg-R2-R3-norLeu-His-Pro-R5;
- wherein R1 is H or Asp;
- R2 is selected from the group consisting of Val and norLeu;
- R3 is selected from the group consisting of Tyr, Tyr(PO3)2, and homoSer;
- R4 is selected from the group consisting of Ile and norLeu;
- and
- R5 is selected from the group consisting of H, Phe, and Ile;
- wherein when the general formula is
- R1-Arg-norLeu-R3-R4-His-Pro-R5
- at least one of the following is true:
- R3 is homoSer;
- R4 is norLeu;
- or
- R5 is selected from the group consisting of H and Ile;
- and
- wherein the general formula is R1-Arg- R2-R3-norLeu-His-Pro-R5, R5 is selected from the group consisting of H and Ile.
15 more elements
Dependencies are inferred from the claim text.