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US 7,022,671 B1Granted
Surfactant protein C esters
AssigneeAltana Pharma AG
InventorsWolf-Rüdiger Ulrich, Ernst Sturm
Life of this patent
Estimating the term…
Abstract
Novel surfactant protein C esters suitable for preparing pharmaceutical compositions for the treatment of infant respiratory distress syndrome and adult respiratory distress syndrome are described.
Claims13
A surfactant protein C (SP-C) having the amino acid sequence SEQ ID NO:
- 3 of the formula I
- 0 1 2 3 4 5 6 7 8 9 10 (I)
- (A) Gly Ile Pro B B Pro Val His Leu Lys
- 11 12 13 14 15 16 17 18 19 20
- Arg Leu Leu Ile Val Val Val Val Val Val
- 21 22 23 24 25 26 27 28 29 30
- Leu Ile Val Val Val Ile Val Gly Ala Leu
- 31 32 33 34
- Leu C Gly Leu
- in which A is absent or Phe, B is Phe or Trp and C is Ile, Leu or Ser,
- wherein the amino acid at the carboxy terminus of the surfactant protein is esterified with an alcohol having 1–4 carbon atoms, and
- wherein the esterified surfactant protein C is isolated and purified,
- or a pharmacologically acceptable salt thereof.
10 more elements
A method of treating Acute Lung Injury (ALI) in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a surfactant protein C(SP-C) having the amino acid sequence SEQ ID NO:
- 3 of the formula I
- 0 1 2 3 4 5 6 7 8 9 10
- (A) Gly Ile Pro B B Pro Val His Leu Lys
- 11 12 13 14 15 16 17 18 19 20
- Arg Leu Leu Ile Val Val Val Val Val Val (I)
- 21 22 23 24 25 26 27 28 29 30
- Leu Ile Val Val Val Ile Val Gly Ala Leu
- 31 32 33 34
- Leu C Gly Leu
- in which A is absent or Phe, B is Phe or Trp and C is Ile, Leu or Ser,
- wherein the amino acid at the carboxy terminus of the surfactant protein is esterified with an alcohol having 1–4 carbon atoms, and
- wherein the esterified surfactant protein C is isolated and purified,
- or a pharmacologically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.