Method of inducing formation of kidney epithelia from mesenchymal precursors
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJonathan M. Barasch, Juan A. Oliver, Jun Yang
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Abstract
This invention provides methods of using a gp130 receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.
Claims5
A method of preserving a kidney for transplantation which comprises contacting the kidney, in the presence of a growth factor, with an amount of a gp130 receptor ligand effective to preserve the kidney wherein the gp130 receptor ligand is chosen from the group consisting of a leukemia inhibitory factor, a cardiotrophin, a ciliary neuronotrophic factor, an interleukin-6, a polypeptide comprising consecutive amino acids having a sequence identical to the sequence of a naturally occurring human leukemia inhibitory factor, and a polypeptide comprising consecutive amino acids having a sequence identical to the sequence of a naturally occurring human growth factor selected from the group consisting of a TGFα, a FGF-2, a FGF-9, a TIMP-1, TIMP-2 and mixtures thereof.
Dependencies are inferred from the claim text.