Process of making a compound by forming a polymer from a template drug
AssigneeMirus Bio Corporation
InventorsVladimir Trubetskoy, Jon A. Wolff, Paul M. Slattum, Lisa Hanson, Vladimir G. Budker, James E. Hagstrom
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Abstract
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
Claims11
A method for delivering a polyion to a cell, comprising:
- a) noncovalently associating polymers with the polyion in a solution outside a cell;
- b) forming covalent linkages between moieties of the polymers in the presence of the polyion without chemically modifying the polyion, thereby forming a complex;
- and,
- c) delivering the complex to the cell.
A method of making a complex for delivery to a cell, comprising:
- a) non-covalently associating a molecule with a polyion in a solution outside a cell;
- and,
- b) covalennly modifying the molecule in the presence of the polyion without chemically modifying the polyion thereby providing a deliverable complex.
A method of making a stabilized complex for delivery to a cell, comprising:
- a) non-covalently associating polymers with a polyion outside a cell to form a complex;
- b) forming covalent linkages between moieties of the polymers in the presence of the polyion without chemically modifying the polyion, thereby forming a stabilized complex.
Dependencies are inferred from the claim text.