Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee
AssigneeThe Trustees of the University of Pennsylvania
InventorsCarl T. Brighton, Solomon R. Pollack
Life of this patent
Estimating the term…
Loading patent…
AssigneeThe Trustees of the University of Pennsylvania
InventorsCarl T. Brighton, Solomon R. Pollack
Estimating the term…
A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffolds, growth factors, etc.) for treating cartilage defects in the human knee joint and a device for delivering such signals to a patient's knee. An analytical model of the human knee is developed whereby the total tissue volume in the human knee may be determined for comparison to the total tissue volume of the diseased tissue in the animal model using electric field and current density histograms. The voltage and current output used in the animal model is scaled based on the ratio of the total tissue volume of the diseased tissue of the human to the total tissue volume of the diseased tissue in the animal model and the resulting field is applied to the diseased tissue of the human using at least two electrodes applied to the knee or a coil or solenoid placed around the knee. The voltage of the signal applied to the electrodes, coil or solenoid is varied based on the size of the knee joint; larger knee joints require larger voltages to generate the effective electric field.
A method of treating diseased tissue in a human through the application of a specific and selective electric or electromagnetic field to the diseased tissue in the human, comprising the steps of:
A device for treating diseased tissue in a human knee joint through the application of a specific and selective electric or electromagnetic field to the diseased or injured tissue in the human knee joint, comprising:
A device for treating osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies for treating cartilage defects in a human knee joint through the application of a specific and selective electric or electromagnetic field to the afflicted tissue in the human knee joint, comprising:
A method of treating osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies for treating cartilage defects in a human knee joint through the application of a specific and selective electric or electromagnetic field to the afflicted tissue in the human knee joint, comprising the steps of:
Dependencies are inferred from the claim text.