Process for the stereoselective preparation of functionalized vicinal diols
AssigneesBayer Aktiengesellschaft, Forschungszentrum Juelich GmbH
InventorsChristian Wandrey, Murillo De Oliveira Villela Filho, Andreas Liese, Jan A. M. De Bont, Jan C. Verdoes, Carel A. G. M. Weijers, J. Hans Visser, Claus Dreisbach
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Abstract
The present invention relates to a process for the kinetic resolution of racemic functionalized epoxides in the presence of microorganisms, crude or pure preparations thereof comprising a polypeptide having epoxide hydrolase activity. Preferred microorganisms are yeasts and bacteria which may also be recombinant.
Claims21
A process for the stereoselective preparation of an 2,3-dihydroxy carboxylic acid and a derivative thereof, comprising
- hydrolyzing a 2,3-epoxycarboxylic acid or a derivative thereof in the in the presence of a polypeptide having epoxide hydrolase activity,
- wherein the 2,3-epoxycarboxylic acid or derivative has a formula (I)
- wherein independently of each other
- R1 represents a cyano substituent and
- R2 represents hydrogen, straight-chain or branched, cyclic or acyclic C1–C12-alkyl, unsubstituted or substituted aryl and
- R3 represents hydrogen, straight-chain C1–C12-alkyl, or
- R2R3C represents a carbocycle or a heterocycle.
A process for preparing 2,3-dihydroxycarboxylic acids and derivatives thereof comprising hydrolyzing 2,3-epoxycarboxylic acids or derivatives thereof in the presence of a microorganism belonging to the basidiomycetous yeast genera Rhodotorula, Rhodosporidium and Trichosporon.
Dependencies are inferred from the claim text.