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US 7,022,487 B2Granted
Compositions and methods for regulating RNA stability using polypyrimidine tract proteins
AssigneeTrustees of Dartmouth College
InventorWilliam F. C. Rigby
Life of this patent
Estimating the term…
Abstract
Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3′-untranslated region of CD154.
Claims3
A method for identifying agents that modulate the level or activity of a polypyrimidine tract protein comprising contacting a test cell, which contains a polypyrimidine tract protein and a cis-acting element of a CD154 3′-untranslated region operatively-linked to a nucleic acid sequence encoding a reporter, with an agent and detecting the expression of a product of the nucleic acid sequence encoding the reporter in the test cell.
Dependencies are inferred from the claim text.