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US 7,022,485 B1Granted
Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
AssigneeUniversite Paul Sabatier
InventorsGuy Serre, Mireille Sebbag
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Abstract
The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
Claims16
A purified citrullinated polypeptide which reacts with rheumatoid arthritis-specific anti-filaggrin autoantibodies, and is selected from the group consisting of:
- a) a citrullinated α-chain of human fibrin;
- b) a citrullinated polypeptide resulting from the action of peptidyl arginine deiminase on an α-chain of human fibrinogen;
- and a fragment of a citrullinated α-chain of human fibrin consisting of at least 5 consecutive amino acids and which also comprises at least one citrulline residue.
Dependencies are inferred from the claim text.