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US 7,022,345 B2Granted
Oral solid pharmaceutical formulations with pH-dependent multiphasic release
OwnerRoberto Valducciinventor
Life of this patent
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Abstract
Oral solid pharmaceutical compositions with pH-dependent multiphasic release, containing, as active ingredient, a molecule useful in the inflammatory bowel disease therapy, are described, being such compositions suitable to the release of the active ingredient in the intestinal tract.
Claims9
A pharmaceutical formulation for multiphasic release of an active ingredient for treating inflammatory bowel disease comprising:
- a plurality of portions of the active ingredient, the plurality of active ingredient portions being an effective amount sufficient to treat inflammatory bowel disease, the formulation having at least three coated active ingredient portions, a first portion having a coating soluble starting from a pH of 6, a second portion having a coating soluble starting from a pH of 6.5 and a third portion having a coating soluble starting from a pH of 7, such that each active ingredient portion is released starting at a pH corresponding to the solubility of the coating thereon.
Dependencies are inferred from the claim text.