Process for producing solid dosage forms
AssigneeBASF SE
InventorsStephan Kothrade, Gunther Berndl, Dirk Simon, Axel Sanner
Life of this patent
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Abstract
A process for producing solid dosage forms by mixing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives to form a plastic mixture, and shaping, wherein a physiologically tolerated, water-swellable graft copolymer or a mixture of graft copolymers is employed as polymeric binder.
Claims10
A process for producing a solid dosage form by mixing at least one polymer binder, at least one active ingredient and optionally conventional additives to form a plastic mixture, and shaping the plastic mixture, wherein the polymeric binder is a water-swellable graft copolymer which is obtained by free radical initiated polymerization of
- a) Cl-C30-alkyl esters, hydroxy-C2-C4-alkyl esters, amides, mono- or di-C1-C4-alkylamides or nitrites of monoethylenically unsaturated C3-C30-mono- or dicarboxylic acids or mixtures thereof in the presence of
- b) homo- or copolymers of C2-C4-alkylene oxides as grafting base, and
- c) optionally one or more monomers having at least two non-conjugated ethylenically unsaturated double bonds,
- and wherein component a) optionally comprises up to 5% by weight, based on the total weight of component a), of an α,β-monoethylenically unsaturated C3-C8-carboxylic acid.
Dependencies are inferred from the claim text.