Therapeutic composition and a method of coating implantable medical devices
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorNi Ding
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Abstract
A therapeutic composition is provided including a polysaccharide or a cationic peptide dissolved in an organic substance. The polysaccharide can be heparin or a derivative of heparin. The cationic peptide can be L-arginine, oligo-L-arginine or poly-L-arginine. The organic substance can be formamide. A method of coating an implantable medical device is also provided, comprising applying the therapeutic composition to the device and allowing the organic substance to evaporate. The device can be a stent.
Claims61
A therapeutic composition comprising a polysaccharide or a cationic peptide dissolved in an organic substance comprising formamide.
A therapeutic composition comprising a polysaccharide or a cationic peptide dissolved in an organic substance, wherein the cationic peptide comprises oligo-L-arginine or poly-L-arginine.
A therapeutic composition comprising (a) a polysaccharide or a cationic peptide or protein;
- (b) formamide;
- and optionally (c) one or a combination of any of a polymer, a therapeutic substance and a solvent for the polymer and/or the therapeutic substance.
A therapeutic composition comprising heparin dissolved in an organic solvent, wherein the organic solvent comprises formamide.
Dependencies are inferred from the claim text.