Recombinant birnavirus vaccine
AssigneeAkzo Nobel N.V.
InventorsHeinrich Dieter Lütticken, Egbert Mundt, Adriaan Anthonius Wilhelmus Maria van Loon
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Abstract
The present invention provides a birnavirus mutant which is suited as vaccine candidate in eradication control programmes. The mutant is not able to produce a native VP5 protein, and this feature can be used as a marker to distinguish between animals vaccinated with the VP5 mutant or infected with a naturally-occurring birnavirus.
Claims8
A non-reverting infectious bursal disease virus (IBDV) mutant which is not able to produce a VP5 protein as a result of a mutation in the VP5 gene of the IBDV genome, wherein the mutation comprises the substitution of at least two nucleotides of the start codon of the VP5 gene.
Dependencies are inferred from the claim text.