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AssigneeProgenics Pharmaceuticals, Inc.
InventorsJames M. Binley, Norbert Schuelke, William C. Olson, Paul J. Maddon, John P. Moore
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This invention provides an isolated nucleic acid which comprises a nucleotide segment having a sequence encoding a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention also provides a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention further provides methods of treating HIV-1 infection.
A complex of a modified form of a gp120 of a HIV-1 isolate and a modified form of an ectodomain of gp41 of such HIV-1 isolate, wherein the modified gp120 comprises an A492C mutation and the modified gp41 ectodomain comprises a T596C mutation, such mutations being numbered by reference to the HIV-1 isolate JR-FL, wherein the modified gp120 and the modified gp41 ectodomain are joined together by an intermolecular disulfide bond which stabilizes the otherwise non-covalent gp120-gp41 ectodomain interaction.
A modified gp140 polypeptide of a HIV-1 isolate, wherein a first portion of the gp140 corresponds to a modified gp120 polypeptide and a second portion of the gp140 corresponds to a modified gp41ectodomain, wherein the modified gp120 comprises an A492C mutation and the modified gp41 ectodomain comprises a T596C mutation, such mutations being numbered by reference to the HIV-1 isolate JR-FL, wherein the modified gp120 and the modified gp41 ectodomain are joined together by an intermolecular disulfide bond which stabilizes the otherwise non-covalent gp120-gp41 ectodomain interaction.
A modified gp140 polypeptide having the amino acid sequence set forth in any of SEQ ID NOs.:
Dependencies are inferred from the claim text.